It was 1964 when eight US marines met in Hanoi. They bonded over a love of hookers, horsepower, motorcycles, and eighty sixin' Charlie. The boys couldn't figure out what to do when the napalm ran out and it was time to haul ass out of the jungle. Until, that is, one of 'em had a the bright idea of startin' a motorcycle club. Thinkin' about all the brothers they'd sent home in bags, they called it The Lost.

Over the years, The Lost MC has faced many challenges, including betrayal, loss, and legal issues. However, they have persevered and have purged their ranks of any weekend warriors or checkbookers. They are a tight-knit group of dedicated, hard-charging members who are willing to die for their club.

In 2015, the Liberty City chapter of The Lost MC received the devastating news that their Vice President, Johnny Klebitz, had been murdered. When they arrived in Los Santos for the funeral, they found that the local chapter had been weakened by its members' addiction to a drug called toilet cleaner and was being overrun by rival groups. The five original members from Liberty City made a pact to revitalize the Blaine County chapter in honor of Johnny and declared war on their rivals.

After a bloody conflict, the existing Blaine County chapter was either wiped out or forced to give up. The new Chapter President has the task of rebuilding the chapter from the ground up, and the story of The Lost MC continues.